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Standard & Poor’s Announces Changes to S&P Index New York, NY, September 16, 2004

Date 16/09/2004

Invitrogen Corp. (NASD:IVGN) will replace Interstate Bakeries Corp. (NYSE:IBC) in the S&P MidCap 400 Index after the close of trading on Monday, September 20, 2004. As of market close on September 15 Interstate Bakeries had a market capitalization of roughly $157 million, ranking 400th in the S&P MidCap 400.

Standard & Poor’s will monitor this transaction, and post any relevant updates on its website: www.standardandpoors.com.

Invitrogen develops, manufactures and markets research products for biotechnology and biopharmaceutical researchers in corporate, academic and governmental organizations. Headquartered in Carlsbad, CA, the company will be added to the S&P MidCap 400 GICS (Global Industry Classification Standard) Biotechnology Sub-Industry Index.

Following is a summary of the change:

S&P MIDCAP 400 INDEX – September 20, 2004
  COMPANY GICS ECONOMIC SECTOR GICS SUB-INDUSTRY
ADDED Invitrogen Corp. Health Care Biotechnology
DELETED Interstate Bakeries Consumer Staples Packaged Foods & Meats

Additions to and deletions from an S&P equity index do not in any way reflect an opinion on the investment merits of the companies concerned.

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